…anaphylaxis challenging.1,8 When anaphylaxis occurs without skin findings, it may not be recognized initially, delaying diagnosis and treatment. In a postmortem case review of fatal anaphylaxis, only 4 of 25…

…anaphylaxis, a rigorous evidence base is lacking. A Cochrane review of the use of epinephrine in anaphylaxis found no randomized or quasi-randomized trials.28 Since epinephrine is accepted as effective, and…

…Anaphylaxis can present with a variety of signs and symptoms. Consider the diagnosis even in patients who do not present with the classic symptoms of urticaria, angioedema, or wheezing. Two studies…

…anaphylaxis. The burden of disease has historically been challenging to quantify because of a lack of consensus on diagnostic criteria, a lack of consistent standards for reporting cases, and ICD-9 miscoding,…

…anaphylaxis, paying particular attention to pulse oximetry and blood pressure (hypotension). Perform a careful assessment of airway patency, looking for stridor, wheezing, dyspnea, or voice change. There are a wide range…

…anaphylaxis may actually worsen underlying ischemia. “My 21-year-old patient had a syncopal episode with bradycardia. It had to have been a vasovagal episode and not anaphylaxis. Besides, she didn’t even have…

…anaphylaxis, meaning 10% of patients with anaphylaxis do not have skin involvement.3,34 Children, especially infants, have additional symptoms to ask about, including irritability, hoarse cry, cyanosis, drooling, and croup-like cough.

…anaphylaxis, they are commonly administered to patients with anaphylactic reactions. These include medications that block both the H1 receptor (eg, diphenhydramine) and H2 receptor (eg, famotidine, cimetidine). Antihistamines are the treatment…

…anaphylaxis, and did not administer epinephrine.” While skin findings (urticaria, mucosal involvement) are common in anaphylaxis, up to 10% of patients with anaphylaxis will not have cutaneous involvement. It is important…

Anaphylaxis is an acute severe systemic type I IgE-mediated hypersensitivity reaction that can be life-threatening. Between 0.4% and 14% of patients will demonstrate biphasic anaphylaxis, with a median time of 18.5…

…anaphylaxis is beneficial, particularly in the acute phase. Epinephrine should be the priority.

…anaphylaxis, acute spinal injury, and bacterial meningitis. While corticosteroids are clearly indicated for management of asthma exacerbations and croup, they are not universally recommended for potential spinal cord injury. Due to…

…anaphylaxis, epinephrine should be administered without delay, with an initial dose of 0.3 to 0.5 mL (0.3-0.5 mg) of the 1 mg/mL concentration given via the intramuscular (IM) route into the…

…anaphylaxis and should be given without delay. Epinephrine is a potent nonselective alpha- and beta-adrenergic agonist. Its action on alpha-1 receptors results in vasoconstriction and a subsequent decrease in mucosal edema.

…anaphylaxis, specifically when associated with hypotension and/or hypoxia. Histamine-mediated angioedema can progress to anaphylaxis, and bradykinin-mediated angioedema becomes life-threatening when swelling progresses to include the larynx.4,6 Understanding the various etiologies…

…anaphylaxis or histamine-mediated angioedema without anaphylaxis, as the mechanism of action of corticosteroids requires the activation and inhibition of a variety of proteins and peptides, leading to a delayed effect. This…

…anaphylaxis and histamine-mediated angioedema; however, serum histamine and tryptase levels are not always elevated, even in patients with severe symptoms.39 Other biomarkers of interest include platelet-activating factor or carboxypeptidase A3;…

…anaphylaxis, soft-tissue infection including abscess, as well as angioedema from the patient’s ACEI use. Your examination was not consistent with infectious etiology, and you realized that labs and imaging wouldn’t be…

…Anaphylaxis may present with hoarseness of the voice in addition to other signs of an allergic reaction, indicating an immediate need for intramuscular epinephrine. A child presenting with stridor and a…

…anaphylaxis. H1 blockers are most useful for symptomatic treatment of urticaria, pruritus, and nasal/ocular symptoms. H2 blockers can be used for gastrointestinal manifestations of anaphylaxis. Bronchodilators aid the management of lower…

…anaphylaxis, airway burns, and vocal cord dysfunction. Chronic stridor usually occurs secondary to congenital conditions, but can also be acquired. Sometimes obstruction from congenital conditions is present at birth, but does…

…anaphylaxis requiring immediate treatment. Facial hemangiomas in the “beard” distribution have been associated symptomatic airway hemangiomas, which should raise the providers concern for airway compromise.137…

…anaphylaxis to modulate latephase response, but there is no consensus or strong evidence to support this common practice.91,100 Albuterol can be considered for bronchospasm unresponsive to the epinephrine. Rapid IV…