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The Pediatric Glasgow Coma Scale allows clinicians to obtain, track, and communicate the mental status and level of consciousness in preverbal children aged ≤ 2 years.
Points to keep in mind:
Why to Use
The pGCS allows for calculation of a GCS score in preverbal children, for whom some of the components in the standard GCS cannot be measured. The standard GCS is a component of several prognostic and clinical decision-making tools, including the PECARN Pediatric Head Injury/Trauma Algorithm, the Revised Trauma Score, the Age-Specific Pediatric Trauma Score, and the Canadian CT Head Injury/Trauma Rule.
When to Use
The pGCS score can be used to assess and track a patient’s mental status and level of consciousness. However, as with the standard.
Joyce Brown, DO, CHSE
Matthew Meigh, DO
All patients with either a pGCS or standard GCS score < 15 need appropriate monitoring, and all patients with concern for mental status or neurologic compromise should be closely monitored and reassessed as needed.
The pGCS was evaluated in a subanalysis of a large, prospective observational multicenter cohort study of children with blunt head trauma, to compare the accuracy of the pGCS in preverbal children (aged ≤ 2 years) to the standard GCS score in older children (aged > 2 years) for identifying patients with TBIs after blunt head trauma (Borgialli 2016). The study demonstrated statistically similar test performance for the pGCS and the standard GCS in identifying patients with ciTBIs. The pGCS had slightly lower accuracy than the standard GCS in identifying patients with TBIs visible on CT. With a 95% confidence interval, the area under the receiver operating characteristic curve for the association between GCS score and ciTBI was 0.77 for the pGCS cohort and 0.81 for the standard GCS cohort. The area under the receiver operating characteristic curve for the association between GCS score and TBI visible on CT was 0.61 for the pGCS cohort and 0.71 for the standard GCS cohort.
Interobserver agreement in each cohort for the total score and all individual score components met the criteria for at least moderate interobserver agreement (kappa 95% lower confidence limit > 0.4). Limitations of the study included an age threshold of ≤ 2 years to define the preverbal pediatric population and the fact that only 36% of the study population underwent cranial CT imaging, so it is possible that some of the children who did not undergo imaging might have had traumatic findings on CT.
Sir Graham Teasdale, MBBS, FRCP
The PECARN Pediatric Head Injury Prediction Rule is a well-validated clinical decision aid that allows clinicians to safely rule out the presence of clinically important traumatic brain injuries.
Why to Use
Unlike in the adult population, CT imaging of the head in pediatric patients is believed to be associated with an increased risk of lethal malignancy over the life of the patient, with the risk decreasing with age. The estimated lifetime risk of lethal malignancy from a head CT scan for a 1-year-old patient is 1 in 1000 to 1 in 1500, with risk decreasing to 1 in 5000 for a 10-year-old patient.
There are over 600,000 ED visits annually in the United States for head trauma among patients aged ≤ 18 years. Applying the PECARN Pediatric Head Injury Prediction Rule allows clinicians to determine which pediatric patients can be safely discharged without a head CT scan.
When to Use
Daniel Runde, MD
Joshua Beiner, MD
In the original PECARN study, ciTBI was a rare event (0.9%), and neurosurgical intervention was even more rare (0.1%). Over 50% of each age cohort did not have any predictors, and CT imaging is not indicated for the vast majority of these patients, as risk of ciTBI was exceedingly low. Risk of ciTBI was > 4% with either of the 2 higher-risk predictors in each age cohort, and imaging is recommended for patients with these predictors.
For the remaining 4 lower-risk predictors in each cohort, the risk of ciTBI is approximately 0.9% per predictor; for patients with any of these risk factors, CT imaging is indicated rather than observation. Judgment may be based on clinical experience, single versus multiple findings, signs of clinical deterioration during the observation period, patient age, and/or parental preference (Kupperman 2009).
The original PECARN study included 42,412 children aged < 18 years presenting to any of the 25 North American PECARN-affiliated emergency departments (EDs). There were 33,785 patients in the derivation cohort (8502 of whom were aged < 2 years) and 8627 in the validation cohort (2216 of whom were aged < 2 years).
CT scans were performed at the physician’s discretion for 35.3% of the patients, while medical records, telephone surveys, and county morgue records were used to assess for cases of missed ciTBI in patients discharged without imaging. The potential for CT reduction quoted above is likely underestimated, given that CT utilization in this study (35.3%) was significantly lower than the estimated average in North American EDs (50%). Among the patients who had CT imaging, 5.2% had TBI visible on CT.
Nine percent of the patients in the study were admitted to the hospital, 0.9% had ciTBIs, 0.1% underwent neurosurgery, and 0 died. Among the 376 patients with ciTBIs, 60 patients (15.9%) underwent neurosurgery, 8 patients (2.1%) were intubated for > 24 hours, and 0 patients died.
In patients aged < 2 years who were negative for any PECARN risk factor, the decision aid was 100% sensitive (95% confidence interval, 86.3-100) with a negative predictive value of 100% (95% confidence interval, 99.7-100) for ruling out ciTBI in the validation cohort. In patients aged > 2 years who were negative for any PECARN risk factor, the aid was 96.8% sensitive (95% confidence interval, 89.0- 99.6) with a 99.95% negative predictive value (95% confidence interval, 99.8-99.99) for ruling out ciTBI in the validation cohort.
As a result of the infrequency of ciTBI, the lower bounds of the confidence intervals of sensitivity started at 86% and 89%, respectively, for the cohorts of patients aged < 2 years and ≥ 2 years. The negative predictive value confidence intervals very closely approximated 100%.
Although the goal was to rule out patients with very low risk of ciTBI, the PECARN Rule also performed well to rule out TBI on head CT. In patients aged < 2 years, sensitivity and negative predictive value were 100% for TBI on CT, with narrow confidence intervals. In patients aged ≥ 2 years, sensitivity was 94% and negative predictive value was 98.4% for TBI on CT, with narrow confidence intervals (Kupperman 2009).
The PECARN Rule has now been externally validated in 2 separate studies. A trial of 2439 children in 2 pediatric EDs (1 in the United States and 1 in Italy) found the PECARN Rule to be 100% sensitive for ruling out ciTBI in both age cohorts (patients aged < 2 years and ≥ 2 years). The rates of 0.8% of patients (19 of 2439) with ciTBI and 0.08% of patients (2 of 2439) requiring neurosurgery were similar to the rates in the PECARN trial (Schonfeld 2014).
A second trial involving 1009 patients aged < 18 years at a single United States ED prospectively compared the PECARN Rule to 2 other pediatric head CT decision aids, CHALICE and CATCH, as well as to physician estimates and physician practice. In this sample, 2% of patients (21 of 1009) had ciTBI and 0.4% of patients (4 of 1009) needed neurosurgery. Again, the PECARN Rule was found to be 100% sensitive for identifying ciTBI. The PECARN Rule outperformed both the CHALICE and CATCH decision aids, which were 91% and 84% sensitive for ciTBI, respectively (Easter 2014).
Two PECARN Rule subgroup analyses attempted to furth er risk stratify patients who had single predictors. In a subanalysis of patients aged < 2 years with scalp hematomas and no other PECARN predictors, ciTBI was too uncommon to apply age, hematoma size, or hematoma location predictors. There were several non–statistically significant trends for higher rates of TBI on head CT scans that may affect imaging tendencies (eg, age < 3 months, nonfrontal hematoma location, and increased hematoma size) (Dayan, Holmes, Schutzman, et al 2014).
Another subanalysis of patients aged > 18 years who had vomiting and no other PECARN predictors reiterated the parent study results. In the cohort of patients aged ≥ 2 years, there was a low rate of TBI on head CT (3.2%, 26 of 806 patients) and an even lower rate of ciTBI (0.7%, 10 of 1501 patients), so observation rather than emergent imaging was indicated in the majority of these patients. The number of vomiting episodes and timing of those episodes was not helpful in predicting ciTBI or TBI on head CT, as there was a non–statistically significant counterintuitive trend towards less ciTBI/TBI on CT with more episodes (Dayan, Holmes, Atabaki, et al 2014).
Nate Kupperman, MD, MPH
Copyright © MDCalc • Reprinted with permission.
Andria Tatem, MD; Rupa Kapoor, MD, FAAP
Michelle Hughes, DO, FAAP; Lara Zibners, MD, MMEd
June 2, 2018