Points & Pearls Excerpt

• Most drug exanthems are benign morbilliform reactions that can be managed in an outpatient setting with discontinuation of the culprit medication and administration of topical corticosteroids and oral antihistamines.
• Some drug reactions can have a delayed onset of up to 8 weeks; a complete medication history from at least the past 2 months is imperative.
• Drug exanthems may continue to worsen for several days even after drug withdrawal.
• Morbilliform drug reactions do not typically require extensive laboratory workup, especially when the history and clinical presentation are indicative of a drug reaction.