Management of Neonatal Rashes in the Emergency Department (Infectious Disease CME) | Points & Pearls
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Management of Neonatal Rashes in the Emergency Department (Infectious Disease CME)

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Points & Pearls Excerpt

  • Neonatal skin findings may be signs of infection including herpes simplex virus (HSV), syphilis, varicella, fungal infections, staphylococcal scalded skin syndrome (SSSS), or staphylococcus/streptococcus toxic shock, all of which have significant morbidity and mortality.
  • It is essential to obtain a comprehensive birth history, detailed maternal history, history from birth up until the time of presentation to the ED, and a thorough family history.
  • Any neonate aged ≤21 days who has a reported or measured temperature of ≥38°C, irrespective of the presence of skin findings, needs a complete infectious workup, defined as blood testing, urine testing, cerebral spinal fluid testing, and viral respiratory testing, if accessible.
  • An unwell-appearing or febrile neonate with a blistering rash requires immediate attention, evaluation, and management for serious infection, including blood work and antimicrobial therapy to cover for multiple potential invasive pathogens.
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Publication Information
Authors

Chelsey Mitchell, MD; Christine T. Lauren, MD, MHA; Kelsey Fawcett, MB, BCh, BAO

Peer Reviewed By

Sylvia E. Garcia, MD; Victoria Gregg, MD

Publication Date

December 1, 2025

CME Expiration Date

December 1, 2028    CME Information

CME Credits

4 AMA PRA Category 1 Credits™, 4 ACEP Category I Credits, 4 AAP Prescribed Credits, 4 AOA Category 2-B Credits.
Specialty CME Credits: Included as part of the 4 credits, this CME activity is eligible for 2 Infectious Disease CME credits, subject to your state and institutional approval.

Pub Med ID: 41252647

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