Updates and Controversies in the Early Management of Sepsis and Septic Shock (Infectious Disease CME and Pharmacology CME)

CME Information

Date of Original Release: August 1, 2025. Date of most recent review: July 10, 2025. Termination date: August 1, 2028.

Accreditation: EB Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation: EB Medicine designates this enduring material for a maximum of 4 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Specialty CME: Included as part of the 4 credits, this CME activity is eligible for 2 Infectious Disease and 2 Pharmacology CME credits, subject to your state and institutional approval. For more information, call Customer Service at 678-366-7933.

ACEP Accreditation: Emergency Medicine Practice is approved by the American College of Emergency Physicians for 48 hours of ACEP Category I credit per annual subscription.

AAFP Accreditation: The AAFP has reviewed Emergency Medicine Practice, and deemed it acceptable for AAFP credit. Term of approval is from 07/01/2025 to 06/30/2026. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This session, Updates and Controversies in the Early Management of Sepsis and Septic Shock, is approved for 4.0 enduring material AAFP Prescribed credits.

AOA Accreditation: Emergency Medicine Practice is eligible for 4 Category 2-B credit hours per issue by the American Osteopathic Association.

Needs Assessment: The need for this educational activity was determined by a practice gap analysis; a survey of medical staff, including the editorial board of this publication; review of morbidity and mortality data from the CDC, AHA, NCHS, and ACEP; and evaluation responses from prior educational activities for emergency physicians.

Target Audience: This enduring material is designed for emergency medicine physicians, physician assistants, nurse practitioners, and residents.

Goals: Upon completion of this activity, you should be able to: (1) identify areas in practice that require modification to be consistent with current evidence in order to improve competence and performance; (2) develop strategies to accurately diagnose and treat both common and critical ED presentations; and (3) demonstrate informed medical decision-making based on the strongest clinical evidence.

CME Objectives: Upon completion of this activity, you should be able to: (1) describe criteria and scoring systems for early recognition of sepsis in patients presenting with signs and symptoms of infection; (2) explain specific recommendations for early management of sepsis and septic shock; and (3) describe and evaluate the evidence basis for sepsis management strategies.

Discussion of Investigational Information: As part of the activity, faculty may be presenting investigational information about pharmaceutical products that is outside Food and Drug Administration approved labeling. Information presented as part of this activity is intended solely as continuing medical education and is not intended to promote off-label use of any pharmaceutical product.

Disclosure: It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME activities. All individuals in a position to control content have disclosed all financial relationships with ACCME-defined ineligible companies. EB Medicine has assessed all relationships with ineligible companies disclosed, identified those financial relationships deemed relevant, and appropriately mitigated all relevant financial relationships based on each individual’s role(s). Please find disclosure information for this activity below:

Planners

• Daniel J. Egan, MD (Course Director, Editor-in-Chief): Nothing to Disclose
• Andy Jagoda, MD (Editor-in-Chief):
  • Johnson & Johnson (Consultant/Advisor)
  • Indivior (Consultant/Advisor)
  • Pfizer (Consultant/Advisor)
  • AstraZeneca (Consultant/Advisor)
• Kaushal Shah, MD (Associate Editor-in-Chief): Nothing to Disclose

Faculty

• Elisabeth H. W. Hwang, MD (Author): Eli Lily (stockholder); Novo Nordisk (stockholder)
• Charles W. Hwang, MD (Author): Nothing to Disclose
• Beulah Augustin, MD (Author): Nothing to Disclose
• Faheem W. Guirgis, MD (Author): Inflammatix (consultant/advisor); Deepull Diagnostics (consultant/advisor); CSL Behring (consultant/ advisor)
• Lauren P. Black, MD, MPH (Author): Nothing to Disclose
• Neil K. Dasgupta, MD (Peer Reviewer): Nothing to Disclose
• Chad M. Meyers, MD (Peer Reviewer): Nothing to Disclose
• Aimee Mishler, PharmD (Pharmacology Editor): Nothing to Disclose
• Joseph D. Toscano, MD (Research Editor): Nothing to Disclose
• Dorothy Whisenhunt, MS (Content Editor): Nothing to Disclose
• Cheryl Belton, PhD (Content Editor): Nothing to Disclose

Commercial Support: This issue of Emergency Medicine Practice did not receive any commercial support.

Earning Credit: Go online to www.ebmedicine.net/CME and click on the title of the test you wish to take. When completed, a CME certificate will be emailed to you.

Additional Policies: For additional policies, including our statement of conflict of interest, source of funding, statement of informed consent, and statement of human and animal rights, visit https://www.ebmedicine.net/policies.