Points & Pearls Excerpt

• Tranexamic acid (TXA) is an antifibrinolytic medication that stabilizes blood clots by inhibiting plasmin and plasminogen-mediated fibrin degradation.¹⁷
• TXA is commercially available as a tablet and an IV solution. These formulations can be readily modified in the ED to fit a variety of clinical needs. (See Table 1.)
• TXA is approved by the United States Food and Drug Administration (FDA) for use in dental extractions for patients with hemophilia and for heavy menstrual bleeding.^3,4 However, TXA has been studied in a variety of other situations, particularly in acute hemorrhage.
• TXA has been studied in a wide range of patient ages, including infants.