Points

• Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of the same condition, differentiated by total body surface area (BSA) involvement: SJS involves <10% BSA, TEN involves >30%, and SJS/TEN overlap involves 10% to 30%.
• Up to 80% of SJS/TEN cases are caused by a medication reaction. Symptoms typically develop within 4 weeks of exposure but can occur up to 8 weeks after initiation.^3-5
• Common causative agents include sulfonamide antibiotics, fluoroquinolones, and antiseizure drugs (eg, carbamazepine, lamotrigine, levetiracetam, and valproate).^3-5 (See Table 1.)