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Urgent Care Evaluation of Pain and Swelling in the Scrotum (Infectious Disease CME and Trauma CME)

Urgent Care Evaluation of Pain and Swelling in the Scrotum (Infectious Disease CME and Trauma CME)
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Publication Date: September 2026 (Volume 5, Number 9)

CME Credits: 4 AMA PRA Category 1 Credits™, 4 ACEP Category I credits, 4 AAFP Prescribed credits, and 4 AOA Category 2-B CME credits. CME expires 09/01/2029.

Authors

Benjamin Silverberg, MD, MSc, FAAFP, FCUCM
Clinical Associate Professor, Division of Primary Care and Population Health, Department of Medicine, Stanford University School of Medicine, Stanford, CA
Ammie Rodden, PA-C
Physician Assistant, Vaden Health Center, Stanford University, Stanford, CA

Abstract

Pain and swelling within the scrotum can indicate a serious condition that may impact fertility or, in some cases, be life-threatening. The differential is broad, ranging from benign conditions to time-sensitive urological and surgical emergencies. Prompt recognition of testicular torsion, testicular rupture, Fournier gangrene, and other serious conditions is essential to prevent testicular loss, impaired fertility, and other complications. This review presents an evidence-based approach to the urgent care evaluation of patients with scrotal or testicular complaints, including sensitive history-taking and physical examination, appropriate use of laboratory testing and ultrasonography, diagnosis and initial management of common conditions, and identification of patients who require referral to a specialist or the emergency department.

Case Presentations

CASE 1

A 14-year-old boy presents to your urgent care clinic with “lower abdominal pain”...

  • You explain to the patient and his mother that the evaluation will include an examination of his abdomen, groin, and genital area. You ask whether he would prefer for his mother to remain in the room or step out. He says he would like for her to step out, so you arrange for a chaperone, in accordance with clinic policy.
  • After his mother leaves the room, the patient tells you that his pain is in the left testicle specifically, began suddenly 6 hours prior, and is associated with nausea and headache.
  • Chaperoned examination reveals a high-riding left testis with horizontal lie, scrotal edema, and tenderness to palpation.
  • You consider the best next step in the management of this patient...
CASE 2

A 40-year-old man presents with testicular pain and dysuria…

  • The patient awoke in bed with a person he did not know, after consuming alcohol at a bar the previous night. He does not recall whether sexual contact occurred. Since then, he has developed urethritis and a dull scrotal ache.
  • After you explain the possible causes of his symptoms, he declines empiric use of ceftriaxone. He is amenable to doxycycline monotherapy while urine testing for gonorrhea and chlamydia is pending.
  • He calls the clinic a week later, reporting continued testicular pain.
  • You wonder if this is an ongoing symptom related to a partially treated sexually transmitted infection…
CASE 3

A 52-year-old man presents with a chief complaint of low back pain...

  • He retired from work as a coal miner approximately 2 years prior. He denies any history of musculoskeletal pains.
  • He endorses fatigue, swelling of the breast tissue, and a sense of heaviness in the scrotum, all of which he attributes to weight gain from being less active and reduced testosterone due to aging.
  • Careful review of his surgical history reveals bilateral orchiopexy for cryptorchidism.
  • You consider referring him for advanced imaging to confirm your suspected diagnosis…