Given the similar physiologic processes of exertional heat stroke and malignant hyperthermia, there is a theoretical benefit for the skeletal muscle relaxant, dantrolene. Although dantrolene reduces muscular heat in malignant hyperthermia, there have been mixed recommendations for its use in heat illness. In a case series of patients with heat-related illness, dantrolene was not found to be effective.103 There is no evidence for the recommendation of dantrolene for the treatment of exertion-related heat illness. The mainstay treatment for heat stroke remains aggressive cooling measures and IV fluid resuscitation.1,54
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