<< Transient Global Amnesia: Emergency Department Evaluation And Management


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Evidence-based medicine requires a critical appraisal of the literature based upon study methodology and number of subjects. Not all references are equally robust. The findings of a large, prospective, randomized, and blinded trial should carry more weight than a case report.

To help the reader judge the strength of each reference, pertinent information about the study is included in bold type following the reference, where available. In addition, the most informative references cited in this paper, as determined by the authors, are noted by an asterisk (*) next to the number of the reference.

  1. * Hodges JR, Ward CD. Observations during transient global amnesia. A behavioural and neuropsychological study of five cases. Brain. 1989;112 (Pt 3):595-620. (Case series; 5 cases)
  2. Brown J. ED evaluation of transient global amnesia. Ann Emerg Med. 1997;30(4):522-526. (Review)
  3. * Quinette P, Guillery-Girard B, Dayan J, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain. 2006;129(Pt 7):1640-1658. (Systematic case series review, 1359 patients; prospective cohort; 142 cases)
  4. No authors listed. The transient global amnesia syndrome. JAMA. 1966;198(7):778-779. (Abstract)
  5. Pearce JM, Bogousslavsky J. ‘Les ictus amnesiques’ and transient global amnesia. Eur Neurol. 2009;62(3):188-192. (Review)
  6. Fisher CM, Adams RD. Transient global amnesia. Acta Neurol Scand Suppl. 1964;40:Suppl 9:1-83. (Review)
  7. Bender MB. Single episode of confusion with amnesia. Bull N Y Acad Med. 1960;36:197-207. (Review)
  8. Munro JM, Loizou LA. Transient global amnesia--familial incidence. J Neurol Neurosurg Psychiatry. 1982;45(11):1070. (Case report; 1 family)
  9. * Hodges JR, Warlow CP. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry. 1990;53(10):834-843. (Retrospective cohort; 153 cases)
  10. Harrison M, Williams M. The diagnosis and management of transient global amnesia in the emergency department. Emerg Med J. 2007;24(6):444-445. (Review)
  11. * Miller JW, Petersen RC, Metter EJ, et al. Transient global amnesia: clinical characteristics and prognosis. Neurology. 1987;37(5):733-737. (Retrospective chart review; 277 cases)
  12. Lauria G, Gentile M, Fassetta G, et al. Incidence of transient global amnesia in the Belluno province, Italy: 1985 through 1995. Results of a community-based study. Acta Neurol Scand. 1997;95(5):303-310. (Retrospective chart review; 96 cases)
  13. Koski KJ, Marttila RJ. Transient global amnesia: incidence in an urban population. Acta Neurol Scand. 1990;81(4):358-360. (Prospective cohort; 78 cases)
  14. Brigo F, Lochner P, Tezzon F, et al. Incidence of transient global amnesia in Merano, province of Bolzano, Italy. Acta Neurol Belg. 2014. (Retrospective chart review)
  15. * Agosti C, Akkawi NM, Borroni B, et al. Recurrency in transient global amnesia: a retrospective study. Eur J Neurol. 2006;13(9):986-989. (Retrospective study; 85 patients)
  16. Lin KH, Chen YT, Fuh JL, et al. Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study. Eur J Neurol. 2014;21(5):718-724. (Case-control study; 158,301 patients)
  17. * Jang JW, Park SY, Hong attack: a large case-control study. Eur Neurol. 2014;71(1-2):19- 24. (Retrospective case-control study; 293 TGA, 632 TIA, 293 control)
  18. * Zorzon M, Antonutti L, Mase G, et al. Transient global amnesia and transient ischemic attack. Natural history, vascular risk factors, and associated conditions. Stroke. 1995;26(9):1536-1542. (Case-control study; 64 TGA, 64 TIA, 108 control)
  19. Mangla A, Navi BB, Layton K, et al. Transient global amnesia and the risk of ischemic stroke. Stroke. 2014;45(2):389-393. (Retrospective case-control study; 25 TGA, 25 other neurologic patients)
  20. Romero JR, Mercado M, Beiser AS, et al. Transient global amnesia and neurological events: the Framingham Heart Study. Front Neurol. 2013;4:47. (Case-control study; 12 TGA, 41 control)
  21. Davies RR, Larner AJ. Familial transient global amnesia. Case Rep Neurol. 2012;4(3):236-239. (Case report; 1 family; review of previous cases reports; 7 families)
  22. Basior J, Vogel S, Mitton J. Transient global amnesia: diagnosis in the emergency department. Am J Emerg Med. 1985;3(4):352-357. (Retrospective chart review; 20 patients)
  23. Corston RN, Godwin-Austen RB. Transient global amnesia in four brothers. J Neurol Neurosurg Psychiatry. 1982;45(4):375- 377. (Case report; 1 family)
  24. Dupuis MJ, Pierre P, Gonsette RE. Transient global amnesia and migraine in twin sisters. J Neurol Neurosurg Psychiatry. 1987;50(6):816-817. (Case report; 1 family)
  25. Segers-van Rijn J, de Bruijn SF. Transient global amnesia: a genetic disorder? Eur Neurol. 2010;63(3):186-187. (Case report; 1 family)
  26. * Dohring J, Schmuck A, Bartsch T. Stress-related factors in the emergence of transient global amnesia with hippocampal lesions. Front Behav Neurosci. 2014;8:287. (Prospective cohort study; 113 patients)
  27. Maloy K, Davis JE. “Forgettable” sex: a case of transient global amnesia presenting to the emergency department. J Emerg Med. 2011;41(3):257-260. (Case report)
  28. Gravlee JR, Barrett JJ. Transient global amnesia in a collegiate baseball player with type I diabetes mellitus: a case report. J Athl Train. 2011;46(3):319-321. (Case report)
  29. Shukla PC, Moore UB. Marijuana-induced transient global amnesia. South Med J. 2004;97(8):782-784. (Case report)
  30. 30. Breitmeier D, Passie T, Mansouri F, et al. Autoerotic accident associated with self-applied ketamine. Int J Legal Med. 2002;116(2):113-116. (Case report)
  31. Mansour G, Abuzaid A, Bellamkonda P. I do not even remember what I smoked! A case of marijuana induced transient global amnesia. Am J Med. 2014;127(11):e5-e6. (Case report)
  32. Magazi D. Amnesia after a half marathon - a case study. Clin J Sport Med. 2012;22(5):448-449. (Case report)
  33. Larner AJ. Amnesia as a sex-related adverse event. Br J Hosp Med (Lond). 2011;72(5):292-293. (Case report)
  34. Chung CP, Hsu HY, Chao AC, et al. Detection of intracranial venous reflux in patients of transient global amnesia. Neurology. 2006;66(12):1873-1877. (Prospective case-control study; 17 TGA, 17 control)
  35. Chung CP, Hsu HY, Chao AC, et al. Transient global amnesia: cerebral venous outflow impairment-insight from the abnormal flow patterns of the internal jugular vein. Ultrasound Med Biol. 2007;33(11):1727-1735. (Prospective case-control study; 10 TGA, 10 control)
  36. Saura D, Penafiel P, Morales A, et al. Transient global amnesia after dobutamine--atropine stress echocardiography. Eur J Echocardiogr. 2008;9(4):567-568. (Case report)
  37. Woolfenden AR, O’Brien MW, Schwartzberg RE, et al. Diffusion-weighted MRI in transient global amnesia precipitated by cerebral angiography. Stroke. 1997;28(11):2311-2314. (Case report)
  38. Adler AC, Warum D, Sapire JM. Transient global amnesia caused by hippocampal infarct: case report and review of literature. Clin Imaging. 2012;36(5):584-586. (Case report and review)
  39. Ay H, Furie KL, Yamada K, et al. Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia. Neurology. 1998;51(3):901-903. (Case report)
  40. Enzinger C, Thimary F, Kapeller P, et al. Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease. Stroke. 2008;39(8):2219-2225. (Retrospective chart review; 86 cases)
  41. Reddy H, Bele K, Misri ZK, et al. Diffusion MRI in transient global amnesia. Neurol India. 2014;62(4):463-465. (Case report)
  42. Schaefer PW. Diffusion-weighted imaging as a problem-solving tool in the evaluation of patients with acute strokelike syndromes. Top Magn Reson Imaging. 2000;11(5):300-309. (Review)
  43. Strupp M, Bruning R, Wu RH, et al. Diffusion-weighted MRI in transient global amnesia: elevated signal intensity in the left mesial temporal lobe in 7 of 10 patients. Ann Neurol. 1998;43(2):164-170. (Longitudinal cohort; 10 patients)
  44. Porth CJ, Bamrah VS, Tristani FE, et al. The Valsalva maneuver: mechanisms and clinical implications. Heart Lung. 1984;13(5):507-518. (Observations)
  45. Tiecks FP, Lam AM, Matta BF, et al. Effects of the Valsalva maneuver on cerebral circulation in healthy adults. A transcranial Doppler study. Stroke. 1995;26(8):1386-1392. (Cross-sectional observational; 10 patients)
  46. Schreiber SJ, Doepp F, Klingebiel R, et al. Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. J Neurol Neurosurg Psychiatry. 2005;76(4):509-513. (Case-control study; 25 TGA, 85 control)
  47. Nedelmann M, Eicke BM, Dieterich M. Increased incidence of jugular valve insufficiency in patients with transient global amnesia. J Neurol. 2005;252(12):1482-1486. (Case-control study; 20 TGA, 20 control)
  48. Sander D, Winbeck K, Etgen T, et al. Disturbance of venous flow patterns in patients with transient global amnesia. Lancet. 2000;356(9246):1982-1984. (Case-control study; 21 TGA, 21 control)
  49. Sander K, Sander D. New insights into transient global amnesia: recent imaging and clinical findings. Lancet Neurol. 2005;4(7):437-444. (Review)
  50. Winbeck K, Etgen T, von Einsiedel HG, et al. DWI in transient global amnesia and TIA: proposal for an ischaemic origin of TGA. J Neurol Neurosurg Psychiatry. 2005;76(3):438- 441. (Prospective case-control study; 74 TIA, 35 TGA)
  51. Maalikjy Akkawi N, Agosti C, Anzola GP, et al. Transient global amnesia: a clinical and sonographic study. Eur Neurol. 2003;49(2):67-71. (Prospective case-control study; 48 TGA, 42 TIA, 48 control)
  52. Akkawi NM, Agosti C, Rozzini L, et al. Transient global amnesia and disturbance of venous flow patterns. Lancet. 2001;357(9260):957. (Case-control study; 30 TGA, 30 control)
  53. Baracchini C, Tonello S, Farina F, et al. Jugular veins in transient global amnesia: innocent bystanders. Stroke. 2012;43(9):2289-2292. (Case-control study; 75 TGA, 75 control)
  54. Kim HY, Kang HS, Roh HG, et al. Transient global amnesia following vertebral artery angioplasty and stenting. Eur J Neurol. 2006;56(2):133-135. (Case report)
  55. Baracchini C, Farina F, Ballotta E, et al. No signs of intracranial arterial vasoconstriction in transient global amnesia. J Neuroimaging. 2015; 25(1):92-96. (Case-control study; 75 TGA, 75 control)
  56. Klotzsch C, Sliwka U, Berlit P, et al. An increased frequency of patent foramen ovale in patients with transient global amnesia. Analysis of 53 consecutive patients. Arch Neurol. 1996;53(6):504-508. (Case-control study; 53 TGA, 69 cerebrovascular disease, 31 control)
  57. Teive HA, Kowacs PA, Maranhao Filho P, et al. Leao’s cortical spreading depression: from experimental “artifact” to physiological principle. Neurology. 2005;65(9):1455-1459. (Historical perspective paper)
  58. Olesen J, Jorgensen MB. Leao’s spreading depression in the hippocampus explains transient global amnesia. A hypothesis. Acta Neurol Scand. 1986;73(2):219-220. (Letter)
  59. Tosi L, Righetti CA. Transient global amnesia and migraine in young people. Clin Neurol Neurosurg. 1997;99(1):63-65. (Case reports; 2 patients)
  60. Schmidtke K, Ehmsen L. Transient global amnesia and migraine. A case control study. Eur Neurol. 1998;40(1):9-14. (Case-control study; 57 TGA, 114 control)
  61. Luhdorf K, Jensen LK, Plesner AM. Epilepsy in the elderly: incidence, social function, and disability. Epilepsia. 1986;27(2):135-141. (Analysis of 5 years of hospital data on patients aged > 60 years in population of 89,000)
  62. Loiseau J, Loiseau P, Duche B, et al. A survey of epileptic disorders in southwest France: seizures in elderly patients. Ann Neurol. 1990;27(3):232-237. (Epidemiological survey)
  63. Tchalla AE, Marin B, Mignard C, et al. Newly diagnosed epileptic seizures: focus on an elderly population on the French island of Reunion in the Southern Indian Ocean. Epilepsia. 2011;52(12):2203-2208. (Retrospective chart review; 182 cases)
  64. * Melo TP, Ferro JM, Ferro H. Transient global amnesia. A case control study. Brain. 1992;115 Pt 1:261-270. (Case-control study; 51 TGA, 102 TIA, 102 control)
  65. Guidotti M, Anzalone N, Morabito A, et al. A case-control study of transient global amnesia. J Neurol Neurosurg Psychiatry. 1989;52(3):320-323. (Case-control study; 30 TGA, 30 TIA, 30 control)
  66. Bilo L, Meo R, Ruosi P, et al. Transient epileptic amnesia: an emerging late-onset epileptic syndrome. Epilepsia. 2009;50:58- 61. (Review)
  67. Greer DM, Schaefer PW, Schwamm LH. Unilateral temporal lobe stroke causing ischemic transient global amnesia: role for diffusion-weighted imaging in the initial evaluation. J Neuroimaging. 2001;11(3):317-319. (Case report)
  68. Gupta M, Kantor MA, Tung CE, et al. Transient global amnesia associated with a unilateral infarction of the fornix: case report and review of the literature. Front Neurol. 2014;5:291. (Case report and review)
  69. Ravindran V, Jain S, Ming A, et al. Transient global amnesia in a patient with acute unilateral caudate nucleus ischemia. J Clin Neurosci. 2004;11(6):669-672. (Case report)
  70. Ott BR, Saver JL. Unilateral amnesic stroke. Six new cases and a review of the literature. Stroke. 1993;24(7):1033-1042. (Case series and review; 6 cases)
  71. Matsukawa H, Uemura A, Fujii M, et al. Morphological and clinical risk factors for the rupture of anterior communicating artery aneurysms. J Neurosurg. 2013;118(5):978-983. (Retrospective chart review; 140 cases)
  72. Maeshima S, Osawa A, Yamane F, et al. Memory impairment caused by cerebral hematoma in the left medial temporal lobe due to ruptured posterior cerebral artery aneurysm. BMC Neurol. 2014;14:44. (Case report)
  73. Monzani V, Rovellini A, Schinco G, et al. Transient global amnesia or subarachnoid haemorrhage? Clinical and laboratory findings in a particular type of acute global amnesia. Eur J Emerg Med. 2000;7(4):291-293. (Case series; 10 patients)
  74. * Hodges JR, Warlow CP. The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up. Brain. 1990;113 ( Pt 3):639-657. (Case-control study; 114 TGA, 212 TIA, 109 control)
  75. Kimura S, Kumano T, Miyao S, et al. Herpes simplex encephalitis with transient global amnesia as an early sign. Intern Med. 1995;34(2):131-133. (Case report)
  76. Stefani A, Riello M, Rossini F, et al. Neurosyphilis manifesting with rapidly progressive dementia: report of three cases Neurol Sci. 2013;34(11):2027-2030. (Case series; 3 patients)
  77. 77. Tsai MY, Tsai MH, Yang SC, et al. Transient global amnesia-like episode due to mistaken intake of zolpidem: drug safety concern in the elderly. J Patient Saf. 2009;5(1):32-34. (Case report)
  78. 78. Kopelman MD. What does a comparison of the alcoholic Korsakoff syndrome and thalamic infarction tell us about thalamic amnesia? Neurosci Biobehav Rev. 2015;54:46-56. (Review)
  79. 79. Pirskanen-Matell R, Grutzmeier S, Nennesmo I, et al. Impairment of short-term memory and Korsakoff syndrome are common in AIDS patients with cytomegalovirus encephalitis. Eur J Neurol. 2009;16(1):48-53. (Prospective cohort study; 254 patients)
  80. Lee H, Roh S, Kim DJ. Alcohol-induced blackout. Int J Environ Res Public Health. 2009;6(11):2783-2792. (Review)
  81. Courand PY, Sibellas F, Gonidec S, et al. Acute myocardial infarction: a precipitating event for transient global amnesia. J Cardiovasc Med (Hagerstown). 2014;15(1):78-79. (Case report)
  82. Caramelli B, Dutra AP, Calderaro D, et al. Transient global amnesia as a manifestation of acute myocardial infarction: a case of missed sudden cardiac death? Int J Cardiol. 2009;136(1):e14-e15. (Case report)
  83. Schlozman SC, Nonacs RM. Massachusetts General Hospital Comprehensive Clinical Psychiatry, 1st ed. Massachusetts General Hospital;2008. (Textbook)
  84. Caplan L, Chedru F, Lhermitte F, et al. Transient global amnesia and migraine. Neurology. 1981;31(9):1167-1170. (Case series; 12 patients)
  85. Morris HH, 3rd, Estes ML. Traveler’s amnesia. Transient global amnesia secondary to triazolam. JAMA. 1987;258(7):945-946. (Case reports; 3 patients)
  86. Ortego-Centeno N, Callejas-Rubio JL, Fernandez MG, et al. Transient global amnesia in a patient with high and persistent levels of antiphospholipid antibodies. Clin Rheumatol. 2006;25(3):407-408. (Case report)
  87. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46(4):1019-1027. (Retrospective chart review)
  88. Viswanathan R, Pilman M, Hasaj M. New-onset amnestic syndrome in AIDS patients with past history of alcohol abuse. Psychosomatics. 1998;39(6):551-553. (Case series; 3 patients)
  89. Tan IL, Smith BR, Hammond E, et al. Older individuals with HIV infection have greater memory deficits than younger individuals. J Neurovirol. 2013;19(6):531-536. (Cohort study; 106 subjects)
  90. Callahan CM, Unverzagt FW, Hui SL, et al. Six-item screener to identify cognitive impairment among potential subjects for clinical research. Med Care. 2002;40(9):771-781. (Cohort study; 995 patients)
  91. Hirschman KB, Paik HH, Pines JM, et al. Cognitive impairment among older adults in the emergency department. West J Emerg Med. 2011;12(1):56-62. (Cross-sectional observational; 829 patients)
  92. Sandson TA, Price BH. Transient global amnesia. Semin Neurol. 1995;15(2):183-187. (Case report and review)
  93. Irioka T, Yamanami A, Yagi Y, et al. Aortic dissection as a possible cause of pure transient global amnesia: a case report and literature review. Neurol Sci. 2009;30(3):255-258. (Case report and review)
  94. Colotto M, Maranghi M, Epifania A, et al. Unmasking aortic dissection in patients of transient global amnesia: case report and diagnostic algorithm for the emergency department. BMJ Case Rep. Published online 2011 Jan 25. doi: 10.1136/ bcr.07.2010.3151. (Case report)
  95. Valenstein E, Bowers D, Verfaellie M, et al. Retrosplenial amnesia. Brain. 1987;110 (Pt 6):1631-1646. (Case report)
  96. Mondon K, Blechet C, Gochard A, et al. Transient global amnesia caused by painless aortic dissection. Emerg Med J. 2007;24(1):63-64. (Case report)
  97. Choi BS, Kim JH, Jung C, et al. High-resolution diffusion-weighted imaging increases lesion detectability in patients with transient global amnesia. AJNR Am J Neuroradiol. 2012;33(9):1771-1774. (Prospective observational; 27 TGA patients)
  98. Ahn S, Kim W, Lee YS, et al. Transient global amnesia: seven years of experience with diffusion-weighted imaging in an emergency department. Eur Neurol. 2011;65(3):123-128. (Retrospective cohort study; 203 TGA patients)
  99. Berli R, Hutter A, Waespe W, et al. Transient global amnesia - not so rare after all. Swiss Med Wkly. 2009;139(19-20):288-292. (Retrospective chart review of 8166 TGA patients; review of 23 consecutive patients)
  100. Kwon Y, Yang Y, Jang JW, et al. Left dominance of EEG abnormalities in patients with transient global amnesia. Seizure. 2014. (Retrospective chart review; 153 TGA patients)
  101. Croft PB, Heathfield KW, Swash M. Differential diagnosis of transient amnesia. Br Med J. 1973;4(5892):593-596. (Case series; 6 cases)
  102. Chow GV, Czarny MJ, Hughes MT, et al. CURVES: a mnemonic for determining medical decision-making capacity and providing emergency treatment in the acute setting. Chest. 2010;137(2):421-427. (Editorial)
  103. Sancesario G, Esposito Z, Mozzi AF, et al. Transient global amnesia: linked to a systemic disorder of amino acid catabolism? J Neurol. 2013;260(5):1429-1432. (Case-control study; 9 TGA, 9 control)
  104. Jalanko M, Forsstrom F, Lassus J. Cardiac troponin T elevation associated with transient global amnesia: another differential diagnosis of ‘troponosis’. Eur Heart J Acute Cardiovasc Care. 2015;4(6):561-564. (Case report)
  105. Horowitz SH. Diagnostic decision-making, burdens of proof, and a $6000 per hour memory lapse. JAMA Intern Med. 2013;173(16):1493-1494. (Case report)


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Jeremy Samuel Faust, MD, MS, MA; Andreea Nemes, MD

Publication Date

August 1, 2016

CME Expiration Date

September 1, 2019

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