The workup required in acutely amnestic patients depends greatly on the patient. In patients with entirely witnessed TGA without concurrent physical signs or symptoms and normal vital signs (ie, not high-risk), the differential diagnosis and diagnostic testing should remain limited. It is not the same as the broader differential for altered mental status. Conversely, acute memory loss in the presence of either concerning vital signs or any other physical, neurologic, or cognitive complaint excludes TGA and requires diagnostic testing tailored to those symptoms.
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