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<< Transient Global Amnesia: Emergency Department Evaluation And Management

Pathophysiology

The pathophysiology of TGA remains controversial, and several theories have been proposed. One theory suggests that TGA is a manifestation of short-lived, reversible ischemia resulting from temporary intracranial venous stasis surrounding the hippocampus, a region found in the medial temporal brain known to be crucial for memory storage. Supporting this theory are case reports of TGA events with abnormal hippocampal findings on magnetic resonance imaging (MRI), some of which resolved on follow-up imaging.38-43 

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