PubMed and the Cochrane Database of Systematic Reviews were searched for English-language articles related to the management of HIV/AIDS. Attention was focused on articles relevant to the emergency clinician, those published after 1996 (to coincide with the advent of HAART), and on articles that discussed the effects of chronic HIV infection and HAART adverse events. Search terms included HIV, AIDS, combination antiretroviral therapy, highly active antiretroviral therapy, and immune reconstitution inflammatory syndrome. Because of the large number of articles retrieved in these searches, the initial focus was on review articles with cross-referencing primary literature cited in the bibliographies. Relevant guidelines by the World Health Organization, the United States Department of Health and Human Services, and the American College of Emergency Physicians were also reviewed.
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