Anaphylaxis and severe allergy are life-threatening episodes of sudden onset that involve inflammatory mediators. It is of paramount importance that emergency clinicians recognize and treat the symptoms early and aggressively to avoid airway compromise or cardiovascular complications in patients. Intra-muscular administration of epinephrine remains the foundation of treatment, along with intravenous fluids for hypotension and distributive shock. Consensus guidelines consistently deem antihistamines and corticosteroids to be second-line treatments, and epinephrine should never be withheld while such other treatments are given.
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