Anaphylaxis can present similarly to a variety of other conditions. (See Table 3) Some of these require swift evaluation and initiation of treatment, and the history will help direct resuscitation and medication administration. Exposure to a potential trigger accompanied by multiple systemic manifestations strongly points to anaphylaxis. However, anaphylactic shock may mimic other hypoperfusion states, such as hypovolemic, endotoxic, hemorrhagic, cardiogenic, or vasovagal reactions, particularly if the anaphylactic response lacks cutaneous/mucosal manifestations such as pruritus, urticaria, or flushing.
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