<< Allergy And Anaphylaxis: Principles Of Acute Emergency Management

Epidemiology, Etiology, And Pathophysiology


There are little data on the prevalence of anaphylaxis. The burden of disease has historically been challenging to quantify because of a lack of consensus on diagnostic criteria, a lack of consistent standards for reporting cases, and ICD-9 miscoding, leading to an under-reporting of anaphylaxis in studies and in the databases.4,5,6 Clinical studies have been performed in many different locations with natural variations in allergen exposure from place to place, which may also contribute to the wide range of prevalence estimates.4 Nonetheless, with these factors taken into consideration, in the United States, the lifetime prevalence of anaphylaxis from all triggers is estimated to be between 0.05% and 2%, with anaphylactic reactions on the rise.2,7,8

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