Many of the variable outcomes in the trials described previously result from differences in the groups studied. While some trials include HF-PEF patients and others predominantly DHF, this variability highlights the lack of a universally accepted classification system for this patient population. This can be explained by the vast number of etiologies of HF-PEF, including patients with no identifiable myocardial pathology. Another controversial aspect of the definition of DHF is the diagnostic tool used for assessment of diastolic function.
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