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<< Sickle Cell Disease: A Comprehensive Review Of Inpatient Management

Additional Considerations

Renal Disease

The prevalence of renal impairment in the SCD population is estimated to be as high as 30%.56 Because of this, annual renal evaluation via serum creatinine and urinalysis for microalbuminuria or proteinuria is recommended for detection of renal insufficiency. In patients who do not have SCD, there is evidence for recommending the use of angiotensin- converting enzyme (ACE) inhibitors for their role in preventing the progression of chronic renal insufficiency.56 While it has not been demonstrated that long-term effects of ACE inhibitors will result in a decrease in proteinuria in patients with SCD, there is potential for benefit.56

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Last Modified: 07/23/2017
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