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<< Evidence-Based Management Of Kawasaki Disease In The Emergency Department

Epidemiology, Etiology, And Pathophysiology

Despite our improved understanding of the immune system activation that occurs in Kawasaki disease, it is still somewhat unclear how it leads to coronary artery aneurysms. Patients with Kawasaki disease have been found to have stimulation of the cytokine cascade and endothelial cell activation. It is this endothelial activation that leads to coronary arteritis and aneurysms, although the exact mechanism of how this occurs still needs to be elucidated.

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