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<< Pediatric Inflammatory Bowel Disease In The Emergency Department: Managing Flares And Long-Term Complications

Etiology And PathophysiologyFor Pediatric Inflammatory Bowel Disease

The exact pathophysiology of IBD is not well understood. There is likely a combination of environmental, genetic, and immunologic factors. An environmental trigger may incite a dysregulation of the immune response to gut flora in a genetically susceptible host.13-15 Patients with IBD have less complex profiles of commensal bacteria and higher numbers of mucosa-associated bacteria as compared to healthy individuals.13 Increased intestinal permeability and food-borne bacterial infections trigger some IBD cases.

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