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<< Transient Ischemic Attack: An Evidence-Based Update (Stroke CME)

Etiology And Pathophysiology

Both TIA and ischemic stroke share the same causes and pathophysiology that lead to focal hypoperfusion, oligemia, and eventual impairment of cerebral oxygen and glucose metabolism. It appears that an individual’s ability to tolerate short periods of cerebral hypoperfusion is variable and dependant upon multiple factors, including collateral flow and oxygen delivery capacity. The phenomenon of ischemic preconditioning appears to provide some degree of protection to certain individuals and is being explored as a novel preventative treatment strategy.28

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