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<< Sickle Cell Disease And Other Hemoglobinopathies: Approaches To Emergency Diagnosis And Treatment

Historical Background And Prevalence

Though SCA and its variants have existed for a long time, it was not until 1910 that the first description of SCD was published, when James Herrick described a case in a 20- year-old dental student.8 The sickle mutation is believed to have evolved due to the selective advantage afforded to the heterozygote carrier (the patient with sickle cell trait) to falciparum malaria. As mentioned, one of every 600 people of African descent in the United States has SCD.3 Additionally, the disease is also found in people of Middle Eastern, Mediterranean, and Indian heritage.6 Interestingly, the combined incidence of all sickle cellvariants approximately equals that of SCD.6

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Last Modified: 07/23/2017
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