The literature was searched using Ovid MEDLINE® and PubMed from 1990 to present. Areas of focus and key words included acute ischemic stroke, computed tomographic angiography, computed tomographic perfusion, multimodal computed tomography, interventional stroke, endovascular stroke, stroke centers, organized stroke care, primary stroke centers, comprehensive stroke centers, healthcare systems, acute stroke with mechanical thrombectomy and intra-arterial thrombolysis. The studies were limited to humans. No language restrictions were applied.
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