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Scorpions: Controversies

Foreign Antivenoms

Due to the expired stockpiles of the C. exilicauda goat derived antivenom, there has been a search for other antivenoms which could potentially treat severe C. exilicauda stings.

In Mexico, two antivenoms have been used to treat Centruroides stings. The Mexico-Pharma Polyvalent Scorpion Antivenom may be effective against North American Centruroides stings, though no reliable repository of this antivenom exists in the United States. In June 2000, Silanes Laboratory received orphan drug status for Alacramyn, which is an equine-derived Fab antivenom specific for Centruroides limpidus, C. noxius, C. suffuses, and C. meisei. Clinical trials in envenomated children are currently in progress in the United States due to the unavailability of the Arizona State University antivenom.96

The incidence of allergic reactions to Alacramyn is reported to be 2.7%, which is similar to the Arizona State University goat-derived antivenom. If the current clinical trials demonstrate that Alacramyn is safe and effective and the FDA approval is granted, the antivenom may become widely available for treatment of severe Centruroides envenomation.94 Alacramyn may be marketed under the name Anascorp in the United States.

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Last Modified: 08/17/2017
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