Sepsis, Severe Sepsis, And Septic Shock: Current Evidence For Emergency Department Management
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Sepsis, Severe Sepsis, And Septic Shock: Current Evidence For Emergency Department Management

May 2011

Abstract

With as many as 700,000 cases of severe sepsis per year in the United States with 500,000 emergency department (ED) presentations, and a mortality of approximately 40%, sepsis presents a significant challenge in healthcare.1,2 Because of the absence of a single gold standard marker of this disease, attempting to identify evidence to support decision-making is extremely difficult.3 However, an organized, evidence-based approach can have an immediate impact in reducing morbidity, mortality, and even cost in sepsis care.4,5 Of sepsis patients initially presenting to the ED, 1 in 5 will remain more than 6 hours, meaning that a majority of the early interventions that have demonstrated short- and longterm improvements are dependent on the emergency clinician’s competence.6 This issue of Emergency Medicine Practice will seek to provide an update on the current understanding of sepsis pathophysiology, to place sepsis in the context of clinical decisionmaking, and to promote early and comprehensive critical care to improve patient outcomes.

Keywords:

sepsis, severe sepsis, septic shock

Table Of Contents:

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