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This article is a publication of the findings of the DEFUSE 3 clinical trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3) that assessed patients with ischemic but not yet infarcted brain tissue (penumbra) as demonstrated on perfusion imaging, who underwent thrombectomy within the 6- to 16-hour timeframe in addition to standard medical therapy. The outcomes were compared to patients who received standard medical therapy alone. The authors concluded that endovascular thrombectomy for ischemic stroke at 6 to 16 hours after symptom onset led to more favorable functional outcomes than standard medical therapy alone among patients with proximal middle cerebral artery or internal carotid artery occlusion and an area of ischemic but not yet infarcted tissue.
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