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The vast majority of pacemakers and implantable cardioverter-defibrillators (ICDs) are considered by device manufacturers and the United States Food and Drug Administration (FDA) to be a contraindication for magnetic resonance imaging (MRI) due to the possibility of device malfunction during the MRI. This article reports the results of a large, single-center, prospective study that assessed the safety of MRI in patients with pacemakers and ICDs that are not labeled as acceptable for MRI.