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According to the United States Centers for Disease Control and Prevention (CDC), opioid-related overdose deaths have become an epidemic. As part of a quality improvement project, this study was designed as a pre- and postintervention time series study in which emergency department (ED) opioid prescription rates were compared during a 7-year period. A group of emergency clinicians in an academic, non–university-affiliated urban hospital with 23,000 annual patient visits agreed to adopt the Washington ED Opioid Abuse Work Group guidelines to limit prescriptions in discharged patients. Their findings support the effectiveness of an opioid-prescribing policy in the ED, with reductions in the rate of opioid prescribing found.