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Review 6: Topical Tranexamic Acid Compared With Anterior Nasal Packing For Treatment Of Epistaxis In Patients Taking Antiplatelet Drugs: Randomized Controlled Trial

Reviewers

Avital N. Porat, MD

Medical Director, Quality & Safety, Hartford Region, Attending Physician, Hartford Hospital; Assistant Professor of Emergency Medicine, University of Connecticut
Hartford, CT

Megan E. Smith, MD, MS

University of Connecticut Integrated Residency in Emergency Medicine
Hartford, CT

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1. Article Citation
2. Synopsis
3. ABEM Quick Quiz
4. Discussion
5. Critique
6. References
7. Editor’s Note
8. ABEM Quick Quiz Answers
9. Key Points
10. Original Article

Article Citation

Zahed R, Jazayeri MHM, Naderi A, et al. Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial. Acad Emerg Med. 2018;25(3):261-266.

Synopsis

This randomized controlled trial compared the efficacy of using topical application of the injectable form of tranexamic acid (TXA) to the use of anterior nasal packing (ANP) in patients taking antiplatelet medications who presented to the emergency department (ED) with epistaxis. Results showed that epistaxis treatment with topical application of TXA resulted in faster bleeding cessation, less rebleeding at 1 week, shorter ED length of stay, and higher patient satisfaction compared to ANP.

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