The ESR is commonly used by emergency clinicians as a biomarker for a number of disease processes, including infection, rheumatologic inflammation, stroke, and malignancy.1-3 Unlike the other biomarkers discussed in this review, ESR is not a single protein with a measurable concentration that can be measured directly. Instead it is—as the name implies—a rate at which red blood cells (RBCs) fall, against gravity, in a tube.
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